Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling | Zendy

Jona B. Krohn | Zendy; Joshua D. Hutcheson | Zendy; Eduardo MartínezMartínez | Zendy; Whitney S. Irvin | Zendy; Carlijn V. C. Bouten | Zendy; Sérgio Bertazzo | Zendy; Michelle P. Bendeck | Zendy; Elena Aïkawa | Zendy

Open Access

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling

Author(s) -

Jona B. Krohn,

Joshua D. Hutcheson,

Eduardo MartínezMartínez,

Whitney S. Irvin,

Carlijn V. C. Bouten,

Sérgio Bertazzo,

Michelle P. Bendeck,

Elena Aïkawa

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307009

Subject(s) - vascular smooth muscle , ddr1 , microbiology and biotechnology , extracellular , transforming growth factor , discoidin domain , growth factor , signal transduction , extracellular vesicles , receptor , cell growth , chemistry , biology , anatomy , smooth muscle , endocrinology , medicine , biochemistry , receptor tyrosine kinase

Collagen accumulation and calcification are major determinants of atherosclerotic plaque stability. Extracellular vesicle (EV)-derived microcalcifications in the collagen-poor fibrous cap may promote plaque rupture. In this study, we hypothesize that the collagen receptor discoidin domain receptor-1 (DDR-1) regulates collagen deposition and release of calcifying EVs by vascular smooth muscle cells (SMCs) through the transforming growth factor-β (TGF-β) pathway.

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