Activation of Peroxisome Proliferator–Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis | Zendy

Jarkko Hytönen | Zendy; Olli Leppänen | Zendy; Jan Hinrich Braesen | Zendy; WolfHagen Schunck | Zendy; Dominik N Mueller | Zendy; F. Jung | Zendy; C. Mrowietz | Zendy; Martin Jastroch | Zendy; Michael von BergweltBaildon | Zendy; Kai Kappert | Zendy; Arnd Heuser | Zendy; JörgDetlef Drenckhahn | Zendy; Burkert Pieske | Zendy; Ludwig Thierfelder | Zendy; Seppo YläHerttuala | Zendy; Florian Blaschke | Zendy

Open Access

Activation of Peroxisome Proliferator–Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis

Author(s) -

Jarkko Hytönen,

Olli Leppänen,

Jan Hinrich Braesen,

WolfHagen Schunck,

Dominik N Mueller,

F. Jung,

C. Mrowietz,

Martin Jastroch,

Michael von BergweltBaildon,

Kai Kappert,

Arnd Heuser,

JörgDetlef Drenckhahn,

Burkert Pieske,

Ludwig Thierfelder,

Seppo YläHerttuala,

Florian Blaschke

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306962

Subject(s) - restenosis , thrombosis , peroxisome proliferator activated receptor , medicine , cardiology , stent , coronary restenosis , receptor

Drug-eluting coronary stents reduce restenosis rate and late lumen loss compared with bare-metal stents; however, drug-eluting coronary stents may delay vascular healing and increase late stent thrombosis. The peroxisome proliferator-activated receptor-delta (PPARδ) exhibits actions that could favorably influence outcomes after drug-eluting coronary stents placement.

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