Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype | Zendy

Gerard Pasterkamp | Zendy; Sander W. van der Laan | Zendy; Saskia Haitjema | Zendy; Hassan Foroughi Asl | Zendy; Marten A. Siemelink | Zendy; Tim Bezemer | Zendy; Jessica van Setten | Zendy; Martin Dichgans | Zendy; Rainer Malik | Zendy; Bradford B. Worrall | Zendy; Heribert Schunkert | Zendy; Nilesh J. Samani | Zendy; Dominique P.V. de Kleijn | Zendy; Hugh S. Markus | Zendy; Imo E. Hoefer | Zendy; Tom Michoel | Zendy; Saskia C.A. de Jager | Zendy; Johan Björkegren | Zendy; Hester M. den Ruijter | Zendy; Folkert W. Asselbergs | Zendy

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Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype

Author(s) -

Gerard Pasterkamp,

Sander W. van der Laan,

Saskia Haitjema,

Hassan Foroughi Asl,

Marten A. Siemelink,

Tim Bezemer,

Jessica van Setten,

Martin Dichgans,

Rainer Malik,

Bradford B. Worrall,

Heribert Schunkert,

Nilesh J. Samani,

Dominique P.V. de Kleijn,

Hugh S. Markus,

Imo E. Hoefer,

Tom Michoel,

Saskia C.A. de Jager,

Johan Björkegren,

Hester M. den Ruijter,

Folkert W. Asselbergs

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306958

Subject(s) - gene , phenotype , disease , pathogenesis , coronary artery disease , biology , stroke (engine) , quantitative trait locus , genome wide association study , genetic association , human genome , genetics , medicine , pathology , immunology , genome , single nucleotide polymorphism , genotype , mechanical engineering , engineering

The genetically modified mouse is the most commonly used animal model for studying the pathogenesis of atherosclerotic disease. We aimed to assess if mice atherosclerosis-related genes could be validated in human disease through examination of results from genome-wide association studies.

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