The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics | Zendy

Ethan P. Marin | Zendy; Levente József | Zendy; Annarita Di Lorenzo | Zendy; Kara F. Held | Zendy; Amelia K. Luciano | Zendy; Jonathan Melendez | Zendy; Leonard M. Milstone | Zendy; Heino Velázquez | Zendy; William C. Sessa | Zendy

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The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics

Author(s) -

Ethan P. Marin,

Levente József,

Annarita Di Lorenzo,

Kara F. Held,

Amelia K. Luciano,

Jonathan Melendez,

Leonard M. Milstone,

Heino Velázquez,

William C. Sessa

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306942

Subject(s) - adrenergic receptor , function (biology) , transferase , chemistry , adrenergic , medicine , receptor , endocrinology , microbiology and biotechnology , biology , enzyme , biochemistry

Palmitoylation, the reversible addition of the lipid palmitate to a cysteine, can alter protein localization, stability, and function. The ZDHHC family of protein acyl transferases catalyzes palmitoylation of numerous proteins. The role of ZDHHC enzymes in intact tissue and in vivo is largely unknown. Herein, we characterize vascular functions in a mouse that expresses a nonfunctional ZDHHC21 (F233Δ).

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