Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis | Zendy

Vladimir R. Babaev | Zendy; Lei Ding | Zendy; Youmin Zhang | Zendy; James M. May | Zendy; P. Charles Lin | Zendy; Sergio Fazio | Zendy; MacRae F. Linton | Zendy

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Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis

Author(s) -

Vladimir R. Babaev,

Lei Ding,

Youmin Zhang,

James M. May,

P. Charles Lin,

Sergio Fazio,

MacRae F. Linton

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306931

Subject(s) - iκb kinase , protein kinase b , biology , pi3k/akt/mtor pathway , phosphorylation , cancer research , macrophage , signal transduction , endocrinology , medicine , microbiology and biotechnology , immunology , nf κb , biochemistry , in vitro

The IκB kinase (IKK) is an enzyme complex that initiates the nuclear factor κB transcription factor cascade, which is important in regulating multiple cellular responses. IKKα is directly associated with 2 major prosurvival pathways, PI3K/Akt and nuclear factor κB, but its role in cell survival is not clear. Macrophages play critical roles in the pathogenesis of atherosclerosis, yet the impact of IKKα signaling on macrophage survival and atherogenesis remains unclear.

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