Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII | Zendy

Jamie M. O’Sullivan | Zendy; P. Vincent Jenkins | Zendy; Orla Rawley | Zendy; Kristina Gegenbauer | Zendy; Alain Chion | Zendy; Michelle Lavin | Zendy; Barry J. Byrne | Zendy; Richard O’Kennedy | Zendy; Roger J. S. Preston | Zendy; Teresa M. Brophy | Zendy; James S. O’Donnell | Zendy

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Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII

Author(s) -

Jamie M. O’Sullivan,

P. Vincent Jenkins,

Orla Rawley,

Kristina Gegenbauer,

Alain Chion,

Michelle Lavin,

Barry J. Byrne,

Richard O’Kennedy,

Roger J. S. Preston,

Teresa M. Brophy,

James S. O’Donnell

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306915

Subject(s) - von willebrand factor , galectin , chemistry , chinese hamster ovary cell , glycan , recombinant dna , galectin 1 , glycosylation , exoglycosidase , galectin 3 , plasma protein binding , in vivo , microbiology and biotechnology , biochemistry , biology , immunology , receptor , glycoprotein , gene , platelet

Recent studies have demonstrated that galectin-1 (Gal-1) and galectin-3 (Gal-3) can bind von Willebrand factor and directly modulate von Willebrand factor-dependent early thrombus formation in vivo. Because the glycans expressed on human factor VIII (FVIII) are similar to those of von Willebrand factor, we investigated whether galectins might also bind and modulate the activity of FVIII.

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