Open AccessFibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice
Author(s) -
Yi Chu,
Donald D. Lund,
Hardik Doshi,
Henry L. Keen,
Kevin L. Knudtson,
N Funk,
Jian Q. Shao,
Justine L. Cheng,
Georges Hajj,
Kathy A. Zimmerman,
Melissa Davis,
Robert Brooks,
Mark W. Chapleau,
Curt D. Sigmund,
Robert M. Weiss,
Donald D. Heistad
Publication year - 2016
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.115.306912
Subject(s) - medicine , stenosis , cardiology , aortic valve , aortic valve stenosis , calcification , fibrosis , endocrinology
Hypercholesterolemia and hypertension are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in hypercholesterolemic/hypertensive mice.
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