Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice | Zendy

Amanda C. Foks | Zendy; Daniel Engelbertsen | Zendy; Felicia Kuperwaser | Zendy; Noah AlbertsGrill | Zendy; Ayelet Gonen | Zendy; Joseph L. Witztum | Zendy; James A. Lederer | Zendy; Petr Jarolı́m | Zendy; Rosemarie H. DeKruyff | Zendy; Gordon J. Freeman | Zendy; Andrew H. Lichtman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

Author(s) -

Amanda C. Foks,

Daniel Engelbertsen,

Felicia Kuperwaser,

Noah AlbertsGrill,

Ayelet Gonen,

Joseph L. Witztum,

James A. Lederer,

Petr Jarolı́m,

Rosemarie H. DeKruyff,

Gordon J. Freeman,

Andrew H. Lichtman

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306860

Subject(s) - efferocytosis , phosphatidylserine , immune system , apoptosis , antibody , phagocytosis , biology , t cell , blockade , microbiology and biotechnology , immunology , receptor , cancer research , chemistry , macrophage , in vitro , biochemistry , phospholipid , membrane

T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regulates the number of phosphatidylserine-expressing activated T cells, and is genetically associated with low low-density lipoprotein and triglyceride levels. Because these functions of Tim-1 and Tim-4 could affect atherosclerosis, their modulation has potential therapeutic value in cardiovascular disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research