Confirmation of the Intracoronary Near-Infrared Spectroscopy Threshold of Lipid-Rich Plaques That Underlie ST-Segment–Elevation Myocardial Infarction | Zendy

Ryan D. Madder | Zendy; Rishi Puri | Zendy; James E. Muller | Zendy; Jan Harnek | Zendy; Matthias Götberg | Zendy; Stacie VanOosterhout | Zendy; Margaret Chi | Zendy; David Wohns | Zendy; Richard McNamara | Zendy; Kathy Wolski | Zendy; Sean Madden | Zendy; S. Sidharta | Zendy; Jordan Andrews | Zendy; Stephen J. Nicholls | Zendy; David Erlinge | Zendy

Open Access

Confirmation of the Intracoronary Near-Infrared Spectroscopy Threshold of Lipid-Rich Plaques That Underlie ST-Segment–Elevation Myocardial Infarction

Author(s) -

Ryan D. Madder,

Rishi Puri,

James E. Muller,

Jan Harnek,

Matthias Götberg,

Stacie VanOosterhout,

Margaret Chi,

David Wohns,

Richard McNamara,

Kathy Wolski,

Sean Madden,

S. Sidharta,

Jordan Andrews,

Stephen J. Nicholls,

David Erlinge

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306849

Subject(s) - culprit , interquartile range , medicine , cardiology , myocardial infarction , st segment , percutaneous coronary intervention

In a previous exploratory analysis, intracoronary near-infrared spectroscopy (NIRS) found the majority of culprit lesions in ST-segment-elevation myocardial infarction (STEMI) to contain a maximum lipid core burden index in 4 mm (maxLCBI4mm) of >400. This initial study was limited by a small sample size, enrollment at a single center, and post hoc selection of the maxLCBI4mm ≥400 threshold. This study was designed a priori to substantiate the ability of NIRS to discriminate STEMI culprit from nonculprit segments and to confirm the performance of the maxLCBI4mm ≥400 threshold.

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