Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier Stabilization | Zendy

Ranjeet Sinha | Zendy; Xia V. Yang | Zendy; José A. Fernández | Zendy; Xiao Xu | Zendy; Laurent O. Mosnier | Zendy; John H. Griffin | Zendy

Open Access

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

Author(s) -

Ranjeet Sinha,

Xia V. Yang,

José A. Fernández,

Xiao Xu,

Laurent O. Mosnier,

John H. Griffin

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306795

Subject(s) - chemistry , microbiology and biotechnology , protein kinase b , receptor , protein c , cancer research , signal transduction , biology , biochemistry

Activated protein C (APC), a plasma serine protease, initiates cell signaling that protects endothelial cells from apoptosis and endothelial barrier disruption. Apolipoprotein E receptor 2 (ApoER2; LRP8) is a receptor known for mediating signaling initiated by reelin in neurons. ApoER2 contributes to APC-initiated signaling in monocytic U937 cells. The objective was to determine whether ApoER2 is required for APC's beneficial signaling in the endothelial cell surrogate EA.hy926 line.

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