Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia | Zendy

Rosanne Turner | Zendy; Kitty W.M. Bloemenkamp | Zendy; Jan A. Bruijn | Zendy; Hans J. Baelde | Zendy

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Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia

Author(s) -

Rosanne Turner,

Kitty W.M. Bloemenkamp,

Jan A. Bruijn,

Hans J. Baelde

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306780

Subject(s) - thrombomodulin , preeclampsia , syncytiotrophoblast , trophoblast , endocrinology , medicine , endothelial dysfunction , endothelium , placenta , andrology , biology , fetus , thrombin , pregnancy , platelet , genetics

Preeclampsia is a pregnancy-specific syndrome characterized by placental dysfunction and an angiogenic imbalance. Systemically, levels of thrombomodulin, an endothelium- and syncytiotrophoblast-bound protein that regulates coagulation, inflammation, apoptosis, and tissue remodeling, are increased. We aimed to investigate placental thrombomodulin dysregulation and consequent downstream effects in the pathogenesis of preeclampsia.

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