Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus | Zendy

Amy P. Chiu | Zendy; Andrea Wan | Zendy; Nathaniel Lal | Zendy; Dahai Zhang | Zendy; Fulong Wang | Zendy; Israël Vlodavsky | Zendy; Bahira Hussein | Zendy; Brian Rodrigues | Zendy

Open Access

Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus

Author(s) -

Amy P. Chiu,

Andrea Wan,

Nathaniel Lal,

Dahai Zhang,

Fulong Wang,

Israël Vlodavsky,

Bahira Hussein,

Brian Rodrigues

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306774

Subject(s) - lipoprotein lipase , medicine , diabetes mellitus , cardiology , lumen (anatomy) , endocrinology , adipose tissue

Lipoprotein lipase (LPL)-mediated triglyceride hydrolysis is the major source of fatty acid for cardiac energy. LPL, synthesized in cardiomyocytes, is translocated across endothelial cells (EC) by its transporter glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1). Previously, we have reported an augmentation in coronary LPL, which was linked to an increased expression of GPIHBP1 following moderate diabetes mellitus. We examined the potential mechanism by which hyperglycemia amplifies GPIHBP1.

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