Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci | Zendy

Yuqi Zhao | Zendy; Jing Chen | Zendy; Johannes Freudenberg | Zendy; Qingying Meng | Zendy; Deepak K. Rajpal | Zendy; Xia Yang | Zendy

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci

Author(s) -

Yuqi Zhao,

Jing Chen,

Johannes Freudenberg,

Qingying Meng,

Deepak K. Rajpal,

Xia Yang

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306725

Subject(s) - coronary artery disease , identification (biology) , prioritization , disease , key (lock) , biology , computational biology , medicine , cardiology , genetics , ecology , process management , business

Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical implications of these findings remain largely unknown. We aim to retrieve gene subnetworks of the 206 CAD loci and identify and prioritize candidate regulators to better understand the biological mechanisms underlying the genetic associations.

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