Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary Hypertension | Zendy

Roger A. Johns | Zendy; Eiki Takimoto | Zendy; Lucas W. Meuchel | Zendy; Esra Elsaigh | Zendy; Ailan Zhang | Zendy; Nicola Heller | Zendy; Gregg L. Semenza | Zendy; Kazuyo Yamaji-Kegan | Zendy

Open Access

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary Hypertension

Author(s) -

Roger A. Johns,

Eiki Takimoto,

Lucas W. Meuchel,

Esra Elsaigh,

Ailan Zhang,

Nicola Heller,

Gregg L. Semenza,

Kazuyo Yamaji-Kegan

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306710

Subject(s) - hypoxia (environmental) , mediator , pulmonary hypertension , hypoxia inducible factors , biology , microbiology and biotechnology , endocrinology , medicine , cancer research , cardiology , chemistry , gene , oxygen , biochemistry , organic chemistry

Pulmonary hypertension (PH) is characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown that in rodents, hypoxia-induced mitogenic factor (HIMF; also known as FIZZ1 or resistin-like molecule-β) causes PH by initiating lung vascular inflammation. We hypothesized that hypoxia-inducible factor-1 (HIF-1) is a critical downstream signal mediator of HIMF during PH development.

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