Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis | Zendy

Rohun U Palekar | Zendy; Andrew Jallouk | Zendy; Jacob W. Myerson | Zendy; Hua Pan | Zendy; Samuel A. Wickline | Zendy

Open Access

Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis

Author(s) -

Rohun U Palekar,

Andrew Jallouk,

Jacob W. Myerson,

Hua Pan,

Samuel A. Wickline

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306697

Subject(s) - thrombin , thrombomodulin , proinflammatory cytokine , inflammation , coagulation , pharmacology , medicine , antithrombin , protein c , pathogenesis , secretion , endothelium , chemistry , platelet , heparin

A role for thrombin in the pathogenesis of atherosclerosis has been suggested through clinical and experimental studies revealing a critical link between the coagulation system and inflammation. Although approved drugs for inhibition of thrombin and thrombin-related signaling have demonstrated efficacy, their clinical application to this end may be limited because of significant potential for bleeding side effects. Thus, we sought to implement a plaque-localizing nanoparticle-based approach to interdict thrombin-induced inflammation and hypercoagulability in atherosclerosis.

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