Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice | Zendy

Marit Westerterp | Zendy; Kyoichiro Tsuchiya | Zendy; Ian Tattersall | Zendy; Panagiotis Fotakis | Zendy; Andrea E. Bochem | Zendy; Matthew M. Molusky | Zendy; Vusisizwe Ntonga | Zendy; Sandra Abramowicz | Zendy; John S. Parks | Zendy; Carrie L. Welch | Zendy; Jan Kitajewski | Zendy; Domenico Accili | Zendy; Alan R. Tall | Zendy

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Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice

Author(s) -

Marit Westerterp,

Kyoichiro Tsuchiya,

Ian Tattersall,

Panagiotis Fotakis,

Andrea E. Bochem,

Matthew M. Molusky,

Vusisizwe Ntonga,

Sandra Abramowicz,

John S. Parks,

Carrie L. Welch,

Jan Kitajewski,

Domenico Accili,

Alan R. Tall

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306670

Subject(s) - atp binding cassette transporter , transporter , microbiology and biotechnology , chemistry , biology , biochemistry , gene

Plasma high-density lipoproteins have several putative antiatherogenic effects, including preservation of endothelial functions. This is thought to be mediated, in part, by the ability of high-density lipoproteins to promote cholesterol efflux from endothelial cells (ECs). The ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) interact with high-density lipoproteins to promote cholesterol efflux from ECs. To determine the impact of endothelial cholesterol efflux pathways on atherogenesis, we prepared mice with endothelium-specific knockout of Abca1 and Abcg1.

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