Microsomal Prostaglandin E Synthase-1–Derived PGE 2 Inhibits Vascular Smooth Muscle Cell Calcification | Zendy

Cheng Gao | Zendy; Yi Fu | Zendy; Yanhui Li | Zendy; Xu Zhang | Zendy; Lu Zhang | Zendy; Fang Yu | Zendy; Susanna S. Xu | Zendy; Qingbo Xu | Zendy; Yi Zhu | Zendy; Youfei Guan | Zendy; Xian Wang | Zendy; Wei Kong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Microsomal Prostaglandin E Synthase-1–Derived PGE ₂ Inhibits Vascular Smooth Muscle Cell Calcification

Author(s) -

Cheng Gao,

Yi Fu,

Yanhui Li,

Xu Zhang,

Lu Zhang,

Fang Yu,

Susanna S. Xu,

Qingbo Xu,

Yi Zhu,

Youfei Guan,

Xian Wang,

Wei Kong

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306642

Subject(s) - vascular smooth muscle , endocrinology , calcification , medicine , downregulation and upregulation , prostaglandin e , prostaglandin , biology , biochemistry , smooth muscle , gene

Chronic administration of selective cyclooxygenase-2 (COX-2) inhibitors leads to an increased risk of adverse cardiovascular events, including myocardial infarction and stroke. Vascular smooth muscle cell (VSMC) calcification, a common complication of chronic kidney disease, is directly related to cardiovascular morbidity and mortality. Here, we tested whether specific COX-2 inhibition affects vascular calcification during chronic renal failure.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research