Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice | Zendy

Jie Hu | Zendy; Wei Hao | Zendy; Mia Jaffe | Zendy; Nathan Airhart | Zendy; Liang Du | Zendy; Stoyan N. Angelov | Zendy; James Yan | Zendy; Julie K. Allen | Zendy; Inkyung Kang | Zendy; Thomas N. Wight | Zendy; Kate Fox | Zendy; Alexandra Smith | Zendy; Rachel Enstrom | Zendy; David A. Dichek | Zendy

Open Access

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice

Author(s) -

Jie Hu,

Wei Hao,

Mia Jaffe,

Nathan Airhart,

Liang Du,

Stoyan N. Angelov,

James Yan,

Julie K. Allen,

Inkyung Kang,

Thomas N. Wight,

Kate Fox,

Alexandra Smith,

Rachel Enstrom,

David A. Dichek

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306573

Subject(s) - biology , receptor , transforming growth factor beta , transforming growth factor , allele , microbiology and biotechnology , cancer research , gene , genetics

Prenatal deletion of the type II transforming growth factor-β (TGF-β) receptor (TBRII) prevents normal vascular morphogenesis and smooth muscle cell (SMC) differentiation, causing embryonic death. The role of TBRII in adult SMC is less well studied. Clarification of this role has important clinical implications because TBRII deletion should ablate TGF-β signaling, and blockade of TGF-β signaling is envisioned as a treatment for human aortopathies. We hypothesized that postnatal loss of SMC TBRII would cause aortopathy.

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