Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function | Zendy

Zhibo Yan | Zendy; Zhen-Guo Wang | Zendy; Nava Segev | Zendy; Sanyuan Hu | Zendy; Richard D. Minshall | Zendy; Randal O. Dull | Zendy; Meihong Zhang | Zendy; Asrar B. Malik | Zendy; Guochang Hu | Zendy

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Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function

Author(s) -

Zhibo Yan,

Zhen-Guo Wang,

Nava Segev,

Sanyuan Hu,

Richard D. Minshall,

Randal O. Dull,

Meihong Zhang,

Asrar B. Malik,

Guochang Hu

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306549

Subject(s) - adherens junction , microbiology and biotechnology , ve cadherin , endothelial stem cell , cadherin , biology , cell adhesion , chemistry , cell , biochemistry , in vitro

Vascular endothelial (VE)-cadherin is the predominant component of endothelial adherens junctions essential for cell-cell adhesion and formation of the vascular barrier. Endocytic recycling is an important mechanism for maintaining the expression of cell surface membrane proteins. However, little is known about the molecular mechanism of VE-cadherin recycling and its role in maintenance of vascular integrity.

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