DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27 KIP1 and Thrombospondin-1 | Zendy

Bahman Rostama | Zendy; Jacqueline E. Turner | Zendy; Guy T. Seavey | Zendy; Christine R. Norton | Zendy; Thomas Gridley | Zendy; Calvin Vary | Zendy; Lucy Liaw | Zendy

Open Access

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27 ^KIP1 and Thrombospondin-1

Author(s) -

Bahman Rostama,

Jacqueline E. Turner,

Guy T. Seavey,

Christine R. Norton,

Thomas Gridley,

Calvin Vary,

Lucy Liaw

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306541

Subject(s) - thrombospondin 1 , microbiology and biotechnology , endothelial stem cell , thrombospondin , signal transduction , cell , angiogenesis , biology , cancer research , chemistry , genetics , in vitro , metalloproteinase , matrix metalloproteinase

Bone morphogenetic protein-9 (BMP9)/activin-like kinase-1 and delta-like 4 (DLL4)/Notch promote endothelial quiescence, and we aim to understand mechanistic interactions between the 2 pathways. We identify new targets that contribute to endothelial quiescence and test whether loss of Dll4(+/-) in adult vasculature alters BMP signaling.

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