Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation | Zendy

Yuko Kato | Zendy; Utako Yokoyama | Zendy; Chiharu Yanai | Zendy; Rina Ishige | Zendy; Daisuke Kurotaki | Zendy; Masanari Umemura | Zendy; Takayuki Fujita | Zendy; Tetsuo Kubota | Zendy; Satoshi Okumura | Zendy; Masataka Sata | Zendy; Tomohiko Tamura | Zendy; Yoshihiro Ishikawa | Zendy

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Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation

Author(s) -

Yuko Kato,

Utako Yokoyama,

Chiharu Yanai,

Rina Ishige,

Daisuke Kurotaki,

Masanari Umemura,

Takayuki Fujita,

Tetsuo Kubota,

Satoshi Okumura,

Masataka Sata,

Tomohiko Tamura,

Yoshihiro Ishikawa

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306534

Subject(s) - vascular smooth muscle , medicine , vascular disease , smooth muscle , cardiology , cancer research

Vascular smooth muscle cell (SMC) migration causes neointima, which is related to vascular remodeling after mechanical injury and atherosclerosis development. We previously reported that an exchange protein activated by cAMP (Epac) 1 was upregulated in mouse arterial neointima and promoted SMC migration. In this study, we examined the molecular mechanisms of Epac1-induced SMC migration and the effect of Epac1 deficiency on vascular remodeling in vivo.

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