Therapeutic Angiogenesis by Ultrasound-Mediated MicroRNA-126-3p Delivery | Zendy

Wei Cao | Zendy; Joshua D. Rosenblat | Zendy; N Roth | Zendy; Michael A. Kuliszewski | Zendy; Pratiek N. Matkar | Zendy; Dmitriy Rudenko | Zendy; Christine Liao | Zendy; Paul J.H. Lee | Zendy; Howard LeongPoi | Zendy

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Therapeutic Angiogenesis by Ultrasound-Mediated MicroRNA-126-3p Delivery

Author(s) -

Wei Cao,

Joshua D. Rosenblat,

N Roth,

Michael A. Kuliszewski,

Pratiek N. Matkar,

Dmitriy Rudenko,

Christine Liao,

Paul J.H. Lee,

Howard LeongPoi

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306506

Subject(s) - angiogenesis , umbilical vein , therapeutic angiogenesis , vascular endothelial growth factor , microbiology and biotechnology , gene knockdown , transfection , cancer research , vascular endothelial growth factor a , angiopoietin , medicine , arteriogenesis , biology , neovascularization , in vitro , cell culture , biochemistry , genetics , vegf receptors

MicroRNAs are involved in many critical functions, including angiogenesis. Ultrasound-targeted microbubble destruction (UTMD) is a noninvasive technique for targeted vascular transfection of plasmid DNA and may be well suited for proangiogenic microRNA delivery. We aimed to investigate UTMD of miR-126-3p for therapeutic angiogenesis in chronic ischemia.

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