IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model | Zendy

Youngho Lee | Zendy; Daiko Wakita | Zendy; Jargalsaikhan Dagvadorj | Zendy; Kenichi Shimada | Zendy; Shuang Chen | Zendy; Ganghua Huang | Zendy; Thomas J A Lehman | Zendy; Michael C. Fishbein | Zendy; Hal M. Hoffman | Zendy; Timothy R. Crother | Zendy; Moshe Arditi | Zendy

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IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model

Author(s) -

Youngho Lee,

Daiko Wakita,

Jargalsaikhan Dagvadorj,

Kenichi Shimada,

Shuang Chen,

Ganghua Huang,

Thomas J A Lehman,

Michael C. Fishbein,

Hal M. Hoffman,

Timothy R. Crother,

Moshe Arditi

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306475

Subject(s) - kawasaki disease , vasculitis , stromal cell , medicine , immunology , critically ill , disease , systemic vasculitis , pathology , cardiology , artery

Kawasaki disease (KD) is the most common cause of acute vasculitis and acquired cardiac disease among US children. We have previously shown that both TLR2/MyD88 and interleukin (IL)-1β signaling are required for the Lactobacillus casei cell wall extract-induced KD vasculitis mouse model. The objectives of this study were to investigate the cellular origins of IL-1 production, the role of CD11c(+) dendritic cells and macrophages, and the relative contribution of hematopoietic and stromal cells for IL-1 responsive cells, as well the MyD88 signaling, in Lactobacillus casei cell wall extract-induced KD mouse model of vasculitis.

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