Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4 | Zendy

Prakash Doddapattar | Zendy; Chintan Gandhi | Zendy; Prem Prakash | Zendy; Nirav Dhanesha | Zendy; Isabella M. Grumbach | Zendy; Michael E. Dailey | Zendy; Steven R. Lentz | Zendy; Anil K. Chauhan | Zendy

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Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4

Author(s) -

Prakash Doddapattar,

Chintan Gandhi,

Prem Prakash,

Nirav Dhanesha,

Isabella M. Grumbach,

Michael E. Dailey,

Steven R. Lentz,

Anil K. Chauhan

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306474

Subject(s) - apolipoprotein e , inflammation , endocrinology , apolipoprotein b , medicine , aortic sinus , biology , m2 macrophage , macrophage , immunology , aorta , cholesterol , in vitro , disease , biochemistry

Cellular fibronectin containing extra domain A (EDA(+)-FN) is abundant in the arteries of patients with atherosclerosis. Several in vitro studies suggest that EDA(+)-FN interacts with Toll-like receptor 4 (TLR4). We tested the hypothesis that EDA(+)-FN exacerbates atherosclerosis through TLR4 in a clinically relevant model of atherosclerosis, the apolipoprotein E-deficient (Apoe(-/-)) mouse.

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