Bone Morphogenic Protein 4-Smad–Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function | Zendy

Weining Hu | Zendy; Yang Zhang | Zendy; Li Wang | Zendy; Chi Wai Lau | Zendy; Jian Xu | Zendy; JiangYun Luo | Zendy; Lingshan Gou | Zendy; Xiaoqiang Yao | Zendy; ZhenYu Chen | Zendy; Ronald C.W. | Zendy; Xiao Yu Tian | Zendy; Yü Huang | Zendy

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Bone Morphogenic Protein 4-Smad–Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function

Author(s) -

Weining Hu,

Yang Zhang,

Li Wang,

Chi Wai Lau,

Jian Xu,

JiangYun Luo,

Lingshan Gou,

Xiaoqiang Yao,

ZhenYu Chen,

Ronald C.W.,

Xiao Yu Tian,

Yü Huang

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306302

Subject(s) - endocrinology , medicine , small hairpin rna , platelet derived growth factor , platelet derived growth factor receptor , biology , growth factor , gene knockdown , receptor , cell culture , genetics

Bone morphogenic protein 4 (BMP4) is an important mediator of endothelial dysfunction in cardio-metabolic diseases, whereas platelet-derived growth factors (PDGFs) are major angiogenic and proinflammatory mediator, although the functional link between these 2 factors is unknown. The present study investigated whether PDGF mediates BMP4-induced endothelial dysfunction in diabetes mellitus.

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