An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation | Zendy

Banumathi K. Cole | Zendy; Michael B. Simmers | Zendy; Ryan E. Feaver | Zendy; Charles W. Qualls | Zendy; Maria Sol Collado | Zendy; Erica Berzin | Zendy; Robert A. Figler | Zendy; Andrew Pryor | Zendy; Mark Lawson | Zendy; Aaron J. Mackey | Zendy; David Manka | Zendy; Brian R. Wamhoff | Zendy; James R. Turk | Zendy; Brett R. Blackman | Zendy

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An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

Author(s) -

Banumathi K. Cole,

Michael B. Simmers,

Ryan E. Feaver,

Charles W. Qualls,

Maria Sol Collado,

Erica Berzin,

Robert A. Figler,

Andrew Pryor,

Mark Lawson,

Aaron J. Mackey,

David Manka,

Brian R. Wamhoff,

James R. Turk,

Brett R. Blackman

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306245

Subject(s) - translation (biology) , drug , in vitro , pharmacology , medicine , computational biology , biology , gene , biochemistry , messenger rna

The predictive value of animal and in vitro systems for drug development is limited, particularly for nonhuman primate studies as it is difficult to deduce the drug mechanism of action. We describe the development of an in vitro cynomolgus macaque vascular system that reflects the in vivo biology of healthy, atheroprone, or advanced inflammatory cardiovascular disease conditions.

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