Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy | Zendy

Thomas Hoefer | Zendy; Paul C. Armstrong | Zendy; Michaela Finsterbusch | Zendy; Melissa V. Chan | Zendy; Nicholas S. Kirkby | Zendy; Timothy D. Warner | Zendy

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Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy

Author(s) -

Thomas Hoefer,

Paul C. Armstrong,

Michaela Finsterbusch,

Melissa V. Chan,

Nicholas S. Kirkby,

Timothy D. Warner

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306219

Subject(s) - platelet , prasugrel , pharmacology , aspirin , chemistry , active metabolite , antiplatelet drug , platelet activation , population , p2y12 , clopidogrel , drug , metabolite , medicine , biochemistry , environmental health

Reduced antiplatelet drug efficacy occurs in conditions of increased platelet turnover, associated with increased proportions of drug-free, that is, uninhibited, platelets. Here, we detail mechanisms by which drug-free platelets promote platelet aggregation in the face of standard antiplatelet therapy.

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