Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking | Zendy

Witold Korytowski | Zendy; Katarzyna Wawak | Zendy; Paweł Pabisz | Zendy; Jared C. Schmitt | Zendy; Alexandra C. Chadwick | Zendy; Daisy Sahoo | Zendy; Albert W. Girotti | Zendy

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Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking

Author(s) -

Witold Korytowski,

Katarzyna Wawak,

Paweł Pabisz,

Jared C. Schmitt,

Alexandra C. Chadwick,

Daisy Sahoo,

Albert W. Girotti

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306210

Subject(s) - abca1 , downregulation and upregulation , chemistry , gene knockdown , cholesterol , oxidative stress , abcg1 , reverse cholesterol transport , mitochondrion , stimulation , cyp27a1 , biochemistry , microbiology and biotechnology , transporter , endocrinology , biology , lipoprotein , apoptosis , gene

Oxidative stress associated with cardiovascular disease can produce various oxidized lipids, including cholesterol oxides, such as 7-hydroperoxide (7-OOH), 7-hydroxide (7-OH), and 7-ketone (7=O). Unlike 7=O and 7-OH, 7-OOH is redox active, giving rise to the others via potentially toxic-free radical reactions. We tested the novel hypothesis that under oxidative stress conditions, steroidogenic acute regulatory (StAR) family proteins not only deliver cholesterol to/into mitochondria of vascular macrophages, but also 7-OOH, which induces peroxidative damage that impairs early stage reverse cholesterol transport.

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