Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans | Zendy

Carlos O. Mendivil | Zendy; Jeremy Furtado | Zendy; Allyson M. Morton | Zendy; Liyun Wang | Zendy; Frank M. Sacks | Zendy

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Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans

Author(s) -

Carlos O. Mendivil,

Jeremy Furtado,

Allyson M. Morton,

Liyun Wang,

Frank M. Sacks

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306138

Subject(s) - apolipoprotein b , clearance , reverse cholesterol transport , cholesterol , medicine , endocrinology , lipoprotein , high density lipoprotein , metabolism , chemistry , endogeny , lipid metabolism , biology , urology

A prevailing concept is that high-density lipoprotein (HDL) is secreted into the systemic circulation as a small mainly discoidal particle, which expands progressively and becomes spherical by uptake and esterification of cellular cholesterol and then contracts by cholesterol ester delivery to the liver, a process known as reverse cholesterol transport, thought to be impaired in people with low HDL cholesterol (HDLc). This metabolic framework has not been established in humans.

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