Protein-Bound Plasma N ε -(Carboxymethyl)lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity–Related Increase in Inflammation | Zendy

Katrien H.J. Gaens | Zendy; Isabel Ferreira | Zendy; Marjo P. H. van de Waarenburg | Zendy; Marleen M. J. van Greevenbroek | Zendy; Carla Kallen | Zendy; Joost Dekker | Zendy; Giel Nijpels | Zendy; Sander S. Rensen | Zendy; Coen D.A. Stehouwer | Zendy; Casper G. Schalkwijk | Zendy

Open Access

Protein-Bound Plasma N ^ε -(Carboxymethyl)lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity–Related Increase in Inflammation

Author(s) -

Katrien H.J. Gaens,

Isabel Ferreira,

Marjo P. H. van de Waarenburg,

Marleen M. J. van Greevenbroek,

Carla Kallen,

Joost Dekker,

Giel Nijpels,

Sander S. Rensen,

Coen D.A. Stehouwer,

Casper G. Schalkwijk

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306106

Subject(s) - waist , adipose tissue , medicine , endocrinology , body mass index , inflammation , insulin resistance , obesity , diabetes mellitus , metabolic syndrome , c reactive protein

Adipose tissue inflammation contributes to the development of complications, such as insulin resistance and type 2 diabetes mellitus. We previously reported that plasma levels of N(ε)-(carboxymethyl)lysine (CML) were decreased in obese subjects resulting from CML accumulation in adipose tissue and that this CML accumulation plays an important role in adipose tissue inflammation. The objective of this study is to investigate associations between obesity (body mass index, waist circumference, and trunk fat mass), plasma CML (as an inversely correlated marker of CML accumulation in adipose tissue), and low-grade inflammation (LGI) in a large sample of individuals whose weight status ranged from normal to morbid obesity.

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