Estrogen-Related Receptor γ Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression
Author(s) -
Ji-Hyun Kim,
YeonKyung Choi,
Ji-Yeon Do,
YoungKeun Choi,
ChaeMyeong Ha,
Sun Joo Lee,
JaeHan Jeon,
Won-Kee Lee,
HuengSik Choi,
KeunGyu Park,
InKyu Lee
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.115.306102
Subject(s) - vascular smooth muscle , downregulation and upregulation , osteopontin , bone morphogenetic protein 2 , calcification , microbiology and biotechnology , endocrinology , medicine , biology , chemistry , in vitro , biochemistry , smooth muscle , gene
Vascular calcification which refers to ectopic mineralization in vascular cells is associated with several conditions, such as chronic kidney disease, atherosclerosis, and diabetes mellitus. Estrogen-related receptor (ERR)γ is a member of the orphan nuclear receptor superfamily, which plays diverse roles in regulating homeostatic and metabolic processes. However, the role of ERRγ in vascular calcification has not been investigated to date. The aim of the present study was to examine the role of ERRγ in vascular calcification.
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