NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells | Zendy

ZhiGang She | Zendy; Yunchao Chang | Zendy; HongBo Pang | Zendy; Wenlong Han | Zendy; HouZao Chen | Zendy; Jeffrey W. Smith | Zendy; William B. Stallcup | Zendy

Open Access

NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells

Author(s) -

ZhiGang She,

Yunchao Chang,

HongBo Pang,

Wenlong Han,

HouZao Chen,

Jeffrey W. Smith,

William B. Stallcup

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306074

Subject(s) - foam cell , smooth muscle , proteoglycan , low density lipoprotein , biophysics , microbiology and biotechnology , chemistry , cell , materials science , lipoprotein , cholesterol , medicine , biochemistry , extracellular matrix , biology

Obesity and hyperlipidemia are critical risk factors for atherosclerosis. Because ablation of NG2 proteoglycan in mice leads to hyperlipidemia and obesity, we investigated the impact of NG2 ablation on atherosclerosis in apoE null mice.

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