S1P 2 /G 12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population | Zendy

Myriam Grimm | Zendy; Denise Tischner | Zendy; Kerstin Troidl | Zendy; Julián Albarrán-Juárez | Zendy; Kishor K. Sivaraj | Zendy; Nerea Ferreirós Bouzas | Zendy; Gerd Geißlinger | Zendy; Christoph J. Binder | Zendy; Nina Wettschureck | Zendy

Open Access

S1P ₂ /G _12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population

Author(s) -

Myriam Grimm,

Denise Tischner,

Kerstin Troidl,

Julián Albarrán-Juárez,

Kishor K. Sivaraj,

Nerea Ferreirós Bouzas,

Gerd Geißlinger,

Christoph J. Binder,

Nina Wettschureck

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306066

Subject(s) - macrophage , microbiology and biotechnology , cell , population , biology , chemistry , genetics , medicine , environmental health , in vitro

Monocyte/macrophage recruitment and activation at vascular predilection sites plays a central role in the pathogenesis of atherosclerosis. Heterotrimeric G proteins of the G12/13 family have been implicated in the control of migration and inflammatory gene expression, but their function in myeloid cells, especially during atherogenesis, is unknown.

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