Open AccessDeubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis
Author(s) -
Nilaksh Gupta,
Wei Li,
Thomas M. McIntyre
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.115.306054
Subject(s) - ubiquitin , proteome , platelet aggregation , platelet , thrombosis , microbiology and biotechnology , chemistry , computational biology , biology , biochemistry , medicine , immunology , gene
Platelets express a functional ubiquitin-proteasome system. Mass spectrometry shows that platelets contain several deubiquitinases, but whether these are functional, modulate the proteome, or affect platelet reactivity are unknown.
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