Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis | Zendy

Travis J. Gould | Zendy; Trang T. Vu | Zendy; Alan R. Stafford | Zendy; Dhruva J. Dwivedi | Zendy; Paul Y. Kim | Zendy; Alison FoxRobichaud | Zendy; Jeffrey I. Weitz | Zendy; Patricia C. Liaw | Zendy

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Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis

Author(s) -

Travis J. Gould,

Trang T. Vu,

Alan R. Stafford,

Dhruva J. Dwivedi,

Paul Y. Kim,

Alison FoxRobichaud,

Jeffrey I. Weitz,

Patricia C. Liaw

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306035

Subject(s) - fibrinolysis , plasmin , fibrin , sepsis , coagulation , plasminogen activator , lysis , neutrophil extracellular traps , medicine , immunology , chemistry , inflammation , biochemistry , enzyme

Sepsis is characterized by systemic activation of inflammation and coagulation in response to infection. In sepsis, activated neutrophils extrude neutrophil extracellular traps composed of cell-free DNA (CFDNA) that not only trap pathogens but also provide a stimulus for clot formation. Although the effect of CFDNA on coagulation has been extensively studied, much less is known about the impact of CFDNA on fibrinolysis. To address this, we (1) investigated the relationship between CFDNA levels and fibrinolytic activity in sepsis and (2) determined the mechanisms by which CFDNA modulates fibrinolysis.

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