PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver | Zendy

Annie Demers | Zendy; Samaneh Samami | Zendy; Benjamin Lauzier | Zendy; Christine Des Rosiers | Zendy; Émilienne T. Ngo Sock | Zendy; Huy Ong | Zendy; Gaétan Mayer | Zendy

Open Access

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver

Author(s) -

Annie Demers,

Samaneh Samami,

Benjamin Lauzier,

Christine Des Rosiers,

Émilienne T. Ngo Sock,

Huy Ong,

Gaétan Mayer

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306032

Subject(s) - cd36 , pcsk9 , triglyceride , endocrinology , medicine , ldl receptor , fatty acid , biology , lipoprotein , proprotein convertase , kexin , scavenger receptor , fatty acid metabolism , lipid metabolism , chemistry , biochemistry , cholesterol , receptor

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein receptor thereby elevating plasma low-density lipoprotein cholesterol levels and the risk of coronary heart disease. Thus, the use of PCSK9 inhibitors holds great promise to prevent heart disease. Previous work found that PCSK9 is involved in triglyceride metabolism, independently of its action on low-density lipoprotein receptor, and that other yet unidentified receptors could mediate this effect. Therefore, we assessed whether PCSK9 enhances the degradation of CD36, a major receptor involved in transport of long-chain fatty acids and triglyceride storage.

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