Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia | Zendy

Xiangwei Liu | Zendy; Xiaolei Sun | Zendy; Hua Liao | Zendy; Zhen Dong | Zendy; Jingjing Zhao | Zendy; Hong Zhu | Zendy; Peng Wang | Zendy; Liguo Shen | Zendy; Lei Xu | Zendy; Xin Ma | Zendy; Cheng Shen | Zendy; Fan Fan | Zendy; Cong Wang | Zendy; Kai Hu | Zendy; Yunzeng Zou | Zendy; Junbo Ge | Zendy; Jun Ren | Zendy; Aijun Sun | Zendy

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Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia

Author(s) -

Xiangwei Liu,

Xiaolei Sun,

Hua Liao,

Zhen Dong,

Jingjing Zhao,

Hong Zhu,

Peng Wang,

Liguo Shen,

Lei Xu,

Xin Ma,

Cheng Shen,

Fan Fan,

Cong Wang,

Kai Hu,

Yunzeng Zou,

Junbo Ge,

Jun Ren,

Aijun Sun

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.306012

Subject(s) - aldh2 , angiogenesis , bone marrow , medicine , vascular endothelial growth factor , ischemia , aldehyde dehydrogenase , progenitor cell , transplantation , endocrinology , stem cell , biology , microbiology and biotechnology , biochemistry , gene , vegf receptors

Revascularization is an essential process to compensate for cardiac underperfusion and, therefore, preserves cardiac function in the face of chronic ischemic injury. Recent evidence suggested a vital role of aldehyde dehydrogenase 2 (ALDH2) in cardiac protection after ischemia. This study was designed to determine whether ALDH2 regulates chronic ischemia-induced angiogenesis and to explore the underlying mechanism involved. Moreover, the clinical impact of the ALDH2 mutant allele on the development of coronary collateral circulation (CCC) was evaluated.

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