Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II–Induced Medial Hyperplasia in the Ascending Aorta | Zendy

Aruna Poduri | Zendy; Debra L. Rateri | Zendy; Deborah A. Howatt | Zendy; Anju Balakrishnan | Zendy; Jessica J. Moorleghen | Zendy; Lisa A. Cassis | Zendy; Alan Daugherty | Zendy

Open Access

Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II–Induced Medial Hyperplasia in the Ascending Aorta

Author(s) -

Aruna Poduri,

Debra L. Rateri,

Deborah A. Howatt,

Anju Balakrishnan,

Jessica J. Moorleghen,

Lisa A. Cassis,

Alan Daugherty

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305995

Subject(s) - angiotensin ii , ascending aorta , renin–angiotensin system , receptor , angiotensin ii receptor type 1 , medicine , angiotensin receptor , endocrinology , chemistry , aorta , blood pressure

Angiotensin II (Ang II) infusion causes aortic medial thickening via stimulation of angiotensin II type 1a (AT1a) receptors. The purpose of this study was to determine the cellular loci of AT1a receptors that mediate this Ang II-induced aortic pathology.

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