Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation | Zendy

JanMarcus Daniel | Zendy; André Prock | Zendy; Jochen Dutzmann | Zendy; Kristina Sonnenschein | Zendy; Thomas Thum | Zendy; Johann Bauersachs | Zendy; Daniel Sedding | Zendy

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Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation

Author(s) -

JanMarcus Daniel,

André Prock,

Jochen Dutzmann,

Kristina Sonnenschein,

Thomas Thum,

Johann Bauersachs,

Daniel Sedding

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305974

Subject(s) - neointima , regulator , microbiology and biotechnology , cell growth , smooth muscle , signal transduction , cell , chemistry , vascular smooth muscle , biology , medicine , endocrinology , biochemistry , restenosis , stent , gene

Regulator of G-protein signaling 5 (RGS5) is abundantly expressed in vascular smooth muscle cells (SMCs) and inhibits G-protein signaling by enhancing the guanosine triphosphate-hydrolyzing activity of Gα-subunits. In the present study, we investigated the effects of RGS5 on vascular SMC function in vitro and neointima formation after wire-induced injury in mice and determined the underlying mechanisms.

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