Open AccessDeficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis
Author(s) -
Sanjana Dayal,
Sean X. Gu,
Ryan Hutchins,
Katina M. Wilson,
Yi Wang,
Xiaoyun Fu,
Steven R. Lentz
Publication year - 2015
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.115.305963
Subject(s) - sod1 , thrombomodulin , superoxide dismutase , protein c , chemistry , superoxide , reactive oxygen species , in vivo , oxidative stress , dismutase , methionine , medicine , endocrinology , thrombin , microbiology and biotechnology , immunology , biology , biochemistry , platelet , enzyme , amino acid
Clinical evidence suggests an association between oxidative stress and vascular disease, and in vitro studies have demonstrated that reactive oxygen species can have prothrombotic effects on vascular and blood cells. It remains unclear, however, whether elevated levels of reactive oxygen species accelerate susceptibility to experimental thrombosis in vivo.
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