Overexpression of Cardiomyocyte α 1A -Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling | Zendy

Xin Zhao | Zendy; Poornima Balaji | Zendy; Ronald Pachon | Zendy; Daniella Beniamen | Zendy; Dorothy E. Vatner | Zendy; Robert M. Graham | Zendy; Stephen F. Vatner | Zendy

Open Access

Overexpression of Cardiomyocyte α _1A -Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling

Author(s) -

Xin Zhao,

Poornima Balaji,

Ronald Pachon,

Daniella Beniamen,

Dorothy E. Vatner,

Robert M. Graham,

Stephen F. Vatner

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305919

Subject(s) - angiogenesis , microbiology and biotechnology , tissue remodeling , receptor , ventricular remodeling , signal transduction , chemistry , biology , medicine , myocardial infarction , cancer research , inflammation

Stimulation of cardiac α1A-adrenergic receptors (α1A-AR) has been proposed for treatment of heart failure, since it increases myocardial contractility. We investigated a different mechanism, induction of angiogenesis.

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