Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype | Zendy

Sarah Gardner | Zendy; Melanie Humphry | Zendy; Martin R. Bennett | Zendy; Murray C.H. Clarke | Zendy

Open Access

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype

Author(s) -

Sarah Gardner,

Melanie Humphry,

Martin R. Bennett,

Murray C.H. Clarke

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305896

Subject(s) - senescence , inflammation , phenotype , vascular smooth muscle , secretion , biology , interleukin , microbiology and biotechnology , smooth muscle , cytokine , immunology , endocrinology , gene , biochemistry

Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process. However, senescent VSMCs are generally considered to only contribute through inaction, with failure to proliferate resulting in VSMC- and collagen-poor unstable fibrous caps. Whether senescent VSMCs can actively contribute to atherogenic processes, such as inflammation, is unknown.

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