High-Density Lipoproteins Reduce Endothelial-to-Mesenchymal Transition | Zendy

Frank Spillmann | Zendy; Kapka Miteva | Zendy; Burkert Pieske | Zendy; Carsten Tschöpe | Zendy; Sophie Van Linthout | Zendy

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High-Density Lipoproteins Reduce Endothelial-to-Mesenchymal Transition

Author(s) -

Frank Spillmann,

Kapka Miteva,

Burkert Pieske,

Carsten Tschöpe,

Sophie Van Linthout

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305887

Subject(s) - smad , mesenchymal stem cell , microbiology and biotechnology , endothelial stem cell , scavenger receptor , chemistry , vascular endothelial growth factor b , transforming growth factor , endocrinology , medicine , biology , vascular endothelial growth factor a , cancer research , vascular endothelial growth factor , lipoprotein , cholesterol , biochemistry , in vitro , vegf receptors

Endothelial-to-mesenchymal transition is an inflammation-induced process by which endothelial cells can transdifferentiate into fibroblasts. Based on the endothelial-protective and antifibrotic effects of high-density lipoproteins (HDL), we aimed to investigate whether HDL can reduce endothelial-to-mesenchymal transition.

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