Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation | Zendy

Abigail S. Haka | Zendy; Rajesh Kumar Singh | Zendy; Inna Grosheva | Zendy; Haley Hoffner | Zendy; Estibaliz CapetilloZarate | Zendy; Harvey F. Chin | Zendy; Niroshana Anandasabapathy | Zendy; Frederick R. Maxfield | Zendy

Open Access

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation

Author(s) -

Abigail S. Haka,

Rajesh Kumar Singh,

Inna Grosheva,

Haley Hoffner,

Estibaliz CapetilloZarate,

Harvey F. Chin,

Niroshana Anandasabapathy,

Frederick R. Maxfield

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305843

Subject(s) - foam cell , downregulation and upregulation , microbiology and biotechnology , extracellular , chemistry , catabolism , monocyte , lipoprotein , low density lipoprotein , immunology , biology , biochemistry , metabolism , cholesterol , gene

Although dendritic cells are known to play a role in atherosclerosis, few studies have examined the contribution of the wide variety of dendritic cell subsets. Accordingly, their roles in atherogenesis remain largely unknown. We investigated the ability of different dendritic cell subsets to become foam cells after contact with aggregated low-density lipoprotein (LDL; the predominant form of LDL found in atherosclerotic plaques).

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