Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women | Zendy

Cara L. Carty | Zendy; Charles Kooperberg | Zendy; Jingmin Liu | Zendy; Megan Herndon | Zendy; Themistocles L. Assimes | Zendy; Lifang Hou | Zendy; Candyce H. Kroenke | Zendy; Andrea Z. LaCroix | Zendy; Masayuki Kimura | Zendy; Abraham Aviv | Zendy; Alexander P. Reiner | Zendy

Open Access

Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women

Author(s) -

Cara L. Carty,

Charles Kooperberg,

Jingmin Liu,

Megan Herndon,

Themistocles L. Assimes,

Lifang Hou,

Candyce H. Kroenke,

Andrea Z. LaCroix,

Masayuki Kimura,

Abraham Aviv,

Alexander P. Reiner

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305838

Subject(s) - medicine , hazard ratio , proportional hazards model , population , demography , confidence interval , environmental health , sociology

Telomeres are regions at the ends of chromosomes that maintain chromosomal structural integrity and genomic stability. In studies of mainly older, white populations, shorter leukocyte telomere length (LTL) is associated with cardiometabolic risk factors and increased risks of mortality and coronary heart disease (CHD). On average, African Americans (AfAm) have longer LTL than whites, but the LTL-CHD relationship in AfAm is unknown. We investigated the relationship of LTL with CHD and mortality among AfAm.

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