Downregulation of Dynamin-Related Protein 1 Contributes to Impaired Autophagic Flux and Angiogenic Function in Senescent Endothelial Cells | Zendy

Jing-Rong Lin | Zendy; Weili Shen | Zendy; Chen Yan | Zendy; Pingjin Gao | Zendy

Open Access

Downregulation of Dynamin-Related Protein 1 Contributes to Impaired Autophagic Flux and Angiogenic Function in Senescent Endothelial Cells

Author(s) -

Jing-Rong Lin,

Weili Shen,

Chen Yan,

Pingjin Gao

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305706

Subject(s) - mitochondrial fission , autophagy , microbiology and biotechnology , downregulation and upregulation , dnm1l , mitochondrion , senescence , gene knockdown , flux (metallurgy) , reactive oxygen species , mitophagy , parkin , chemistry , dynamin , autophagosome , biology , apoptosis , cell , endocytosis , medicine , biochemistry , organic chemistry , gene , disease , parkinson's disease

Recent studies have shown that altered mitochondrial dynamics impairs the function in senescent endothelial cells (ECs). However, the underlying molecular mechanism remains to be elucidated. Herein, we investigated the role and underlying mechanism of mitochondrial fission protein dynamin-related protein 1 (DRP1) in vascular aging.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research