Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages | Zendy

Alexis Varin | Zendy; Charles Thomas | Zendy; Minako Ishibashi | Zendy; Louise Ménégaut | Zendy; Thomas Gautier | Zendy; Amalia Trousson | Zendy; Victoria Bergas | Zendy; Jean-Paul Paı̈s de Barros | Zendy; Michel Narce | Zendy; Jean Marc Lobaccaro | Zendy; Laurent Lagrost | Zendy; David Masson | Zendy

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Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages

Author(s) -

Alexis Varin,

Charles Thomas,

Minako Ishibashi,

Louise Ménégaut,

Thomas Gautier,

Amalia Trousson,

Victoria Bergas,

Jean-Paul Paı̈s de Barros,

Michel Narce,

Jean Marc Lobaccaro,

Laurent Lagrost,

David Masson

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305539

Subject(s) - liver x receptor , docosahexaenoic acid , arachidonic acid , polyunsaturated fatty acid , biochemistry , eicosapentaenoic acid , fatty acid , fatty acid synthase , cyp2c8 , biology , chemistry , nuclear receptor , metabolism , enzyme , cytochrome p450 , cyp3a4 , transcription factor , gene

Liver X receptors (LXRs) modulate cholesterol and fatty acid homeostasis as well as inflammation. This study aims to decipher the role of LXRs in the regulation of polyunsaturated fatty acid (PUFA) synthesis in macrophages in the context of atherosclerosis.

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