Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm | Zendy

A. Phillip Owens | Zendy; Todd L. Edwards | Zendy; Silvio Antoniak | Zendy; Julia E. Geddings | Zendy; Eiman Jahangir | Zendy; WeiQi Wei | Zendy; Joshua C. Denny | Zendy; Yacine Boulaftali | Zendy; Wolfgang Bergmeier | Zendy; Alan Daugherty | Zendy; Uchechukwu K.A. Sampson | Zendy; Nigel Mackman | Zendy

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Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm

Author(s) -

A. Phillip Owens,

Todd L. Edwards,

Silvio Antoniak,

Julia E. Geddings,

Eiman Jahangir,

WeiQi Wei,

Joshua C. Denny,

Yacine Boulaftali,

Wolfgang Bergmeier,

Alan Daugherty,

Uchechukwu K.A. Sampson,

Nigel Mackman

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305537

Subject(s) - abdominal aortic aneurysm , medicine , platelet , cardiology , population , aneurysm , platelet activation , aortic aneurysm , angiotensin ii , vascular disease , disease , surgery , receptor , environmental health

Rupture of abdominal aortic aneurysms causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of aneurysms and may contribute to disease progression. In this study, we used a pharmacological approach to examine a role of platelets in established aneurysms induced by angiotensin II infusion into hypercholesterolemic mice.

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