Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries | Zendy

Mélissa Beaudoin | Zendy; Rajat M. Gupta | Zendy; HongHee Won | Zendy; Ken Sin Lo | Zendy; Ron Do | Zendy; Christopher A. Henderson | Zendy; Claire Lavoie-St-Amour | Zendy; Simon Langlois | Zendy; Daniel Rivas | Zendy; Stéphanie Lehoux | Zendy; Sekar Kathiresan | Zendy; JeanClaude Tardif | Zendy; Yan V. Sun | Zendy; Guillaume Lettre | Zendy

Open Access

Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries

Author(s) -

Mélissa Beaudoin,

Rajat M. Gupta,

HongHee Won,

Ken Sin Lo,

Ron Do,

Christopher A. Henderson,

Claire Lavoie-St-Amour,

Simon Langlois,

Daniel Rivas,

Stéphanie Lehoux,

Sekar Kathiresan,

JeanClaude Tardif,

Yan V. Sun,

Guillaume Lettre

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305534

Subject(s) - biology , genome wide association study , locus (genetics) , genetics , single nucleotide polymorphism , expression quantitative trait loci , snp , gene , genotype

Coronary artery disease (CAD), including myocardial infarction (MI), is the main cause of death in the world. Genome-wide association studies have identified dozens of single nucleotide polymorphisms (SNPs) associated with CAD/MI. One of the most robust CAD/MI genetic associations is with intronic SNPs in the gene PHACTR1 on chromosome 6p24. How these PHACTR1 SNPs influence CAD/MI risk, and whether PHACTR1 itself is the causal gene at the locus, is currently unknown.

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