Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm | Zendy

Kuan-Chieh Wang | Zendy; Yi-Heng Li | Zendy; Guey-Yueh Shi | Zendy; Hung-Wen Tsai | Zendy; Chawn-Yau Luo | Zendy; Min-Hua Cheng | Zendy; Chih-Yuan Ma | Zendy; Yun-Yan Hsu | Zendy; TsungLin Cheng | Zendy; Bi-Ing Chang | Zendy; ChaoHan Lai | Zendy; HuaLin Wu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm

Author(s) -

Kuan-Chieh Wang,

Yi-Heng Li,

Guey-Yueh Shi,

Hung-Wen Tsai,

Chawn-Yau Luo,

Min-Hua Cheng,

Chih-Yuan Ma,

Yun-Yan Hsu,

TsungLin Cheng,

Bi-Ing Chang,

ChaoHan Lai,

HuaLin Wu

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.305529

Subject(s) - thrombomodulin , abdominal aortic aneurysm , macrophage , inflammation , medicine , aneurysm , cardiology , aortic aneurysm , chemistry , radiology , biochemistry , thrombin , platelet , in vitro

Thrombomodulin (TM), a glycoprotein constitutively expressed in the endothelium, is well known for its anticoagulant and anti-inflammatory properties. Paradoxically, we recently found that monocytic membrane-bound TM (ie, endogenous TM expression in monocytes) triggers lipopolysaccharide- and gram-negative bacteria-induced inflammatory responses. However, the significance of membrane-bound TM in chronic sterile vascular inflammation and the development of abdominal aortic aneurysm (AAA) remains undetermined.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research